Highly active antiretroviral therapy is necessary but not sufficient. A systematic review and meta-analysis of mortality ... - BMC Public Health
The Joint United Nations Programme on HIV/AIDS (UNAIDS). Global HIV statistics. Fact sheet 2023 epidemiological estimates. https://www.unaids.org/en/resources/fact-sheet.
HIV statistics, globally and by WHO region, 2023. Epidemiological fact sheet. https://cdn.who.int/media/docs/default-source/hq-hiv-hepatitis-and-stis-library/j0294-who-hiv-epi-factsheet-v7.pdf.
Cao G, et al. Prevalence of anemia among people living with HIV: a systematic review and meta-analysis. EClinicalMedicine. 2022;44:101283.
Lawn SD, et al. Early mortality among adults accessing antiretroviral treatment programs in sub-Saharan Africa. AIDS. 2008;22(15):1897–908.
Braitstein P, et al. Mortality of HIV-1-infected patients in the first year of antiretroviral therapy: comparison between low-income and high-income countries. Lancet (London, England). 2006;367(9513):817–24.
The Ethiopian Public Health Institute (EPHI). HIV estimates and projections for the years 2022 and 2023. https://ephi.gov.et/wp-content/uploads/2021/02/HIV-Estimates-and-Projection-for-the-year-2022-and-2023.pdf.
The Federal Ministry of Health of Ethiopia (FMOH). National guidelines for comprehensive HIV prevention, care, and treatment. 2023.
Stringer JS, et al. Rapid scale-up of antiretroviral therapy at primary care sites in Zambia: feasibility and early outcomes. JAMA. 2006;296(7):782–93.
Toure S, et al. Rapid scaling-up of antiretroviral therapy in 10,000 adults in Cote d'Ivoire: two-year outcomes and determinants. AIDS (London, England). 2008;22(7):873.
Lawn SD, et al. Early mortality among adults accessing a community-based antiretroviral service in South Africa: implications for programme design. AIDS. 2005;19(18):2141–8.
De Iaco G, et al. Factors predicting early death in a cohort of patients with HIV/AIDS in Burkina Faso: the need for earlier diagnosis and antiretroviral treatment. In: Abstract Book 4th IAS Conference on HIV Pathogenesis, Treatment and Prevention. International AIDS Society; 2007.
Etard J-F, et al. Mortality and causes of death in adults receiving highly active antiretroviral therapy in Senegal: a 7-year cohort study. AIDS. 2006;20(8):1181–9.
Ferradini L, et al. Scaling up of highly active antiretroviral therapy in a rural district of Malawi: an effectiveness assessment. lancet. 2006;367(9519):1335–42.
Zachariah R, et al. Risk factors for high early mortality in patients on antiretroviral treatment in a rural district of Malawi. AIDS. 2006;20(18):2355–60.
Moh R, et al. Incidence and determinants of mortality and morbidity following early antiretroviral therapy initiation in HIV-infected adults in West Africa. AIDS. 2007;21(18):2483–91.
Laurent C, et al. Long-term benefits of highly active antiretroviral therapy in Senegalese HIV-1-infected adults. J Acquir Immune Defic Syndr. 2005;38(1):14–7.
Coetzee D, et al. Outcomes after two years of providing antiretroviral treatment in Khayelitsha, South Africa. Aids. 2004;18(6):887–95.
Lawn SD, et al. Determinants of mortality and non-death losses from an antiretroviral treatment service in South Africa: implications for program evaluation. Clin Infect Dis. 2006;43(6):770–6.
Lawn SD, et al. Burden of tuberculosis in an antiretroviral treatment program in sub-Saharan Africa: impact on treatment outcomes and implications for tuberculosis control. AIDS. 2006;20(12):1605–12.
Moore D, et al. Prevalence, incidence and mortality associated with tuberculosis in HIV-infected patients initiating antiretroviral therapy in rural Uganda. AIDS. 2007;21(6):713–9.
Nachega JB, et al. Adherence to highly active antiretroviral therapy assessed by pharmacy claims predicts survival in HIV-infected South African adults. J Acquir Immune Defic Syndr. 2006;43(1):78–84.
Lawn SD, et al. Early mortality among adults accessing antiretroviral treatment programs in sub-Saharan Africa. AIDS (London, England). 2008;22(15):1897–908.
Misgina KH, et al. Predictors of mortality among adult people living with HIV/AIDS on antiretroviral therapy at Suhul Hospital, Tigrai, Northern Ethiopia: a retrospective follow-up study. J Health Popul Nutr. 2019;38(1):37.
Tadele A, Shumey A, Hiruy N. Survival and predictors of mortality among adult patients on highly active antiretroviral therapy at debre-markos referral Hospital, North West Ethiopia; a retrospective cohort study. J AIDS Clin Res. 2014;5:2.
Shamseer L, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation. BMJ. 2015:349. https://doi.org/10.1136/bmj.g7647.
Page MJ, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71.
Aromataris E, Munn Z. Chapter 1: JBI Systematic Reviews. In: Aromataris E, editor. JBI Manual for Evidence Synthesis. 2020.
Higgins JP, et al. Cochrane handbook for systematic reviews of interventions. John Wiley & Sons; 2019.
Egger M, et al. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315(7109):629–34.
Gebremichael SG. AIDS-duration predictors of HIV/AIDS patients on antiretroviral therapy at Debre Berhan referral hospital, north-central Ethiopia. MOJ Public Health. 2020;9(4):99–105.
Tsegaye E, Worku A. Assessment of antiretroviral treatment outcome in public hospitals, South Nations Nationalities and Peoples, Region Ethiopia. Ethiop J Health Dev. 2011;25(2):102–9.
Hambisa MT, Ali A, Dessie Y. Determinants of mortality among HIV positives after initiating antiretroviral therapy inwestern ethiopia: a hospital-based retrospective cohort study. ISRN AIDS. 2013;2013:1–8.
Abebe TW, et al. Determinants of survival among adults on antiretroviral therapy in Adama Hospital Medical College, Oromia Regional state, Ethiopia. J HIV AIDS (ISSN 2380–5536 ). 2016;2(1).
Alemu AW, Sebastian MS. Determinants of survival in adult HIV patients on antiretroviral therapy in Oromiyaa, Ethiopia. Glob Health Action. 2010:3.
Hailemariam S, et al. Determinants of survival in HIV patients: a retrospective study of Dilla University Hospital HIV cohort. Int J Virol AIDS. 2016;3(2):2–6.
Girum T, et al. The effect of "universal test and treat" program on HIV treatment outcomes and patient survival among a cohort of adults taking antiretroviral treatment (ART) in low-income settings of Gurage zone, South Ethiopia. AIDS Res Ther. 2020;17(1):19.
Belay H, et al. Effect of late HIV diagnosis on HIV-related mortality among adults in general hospitals of Central Zone Tigray, northern Ethiopia: a retrospective cohort study. HIV AIDS (Auckl). 2017;9:187–92.
Tesfaye B, et al. Effect of the test and treat strategy on mortality among HIV-positive adult clients on antiretroviral treatment in public Hospitals of Addis Ababa. Ethiopia HIV AIDS (Auckl). 2021;13:349–60.
Kebede A, et al. Epidemiology of survival pattern and its predictors among HIV positive patients on highly active antiretroviral therapy in Southern Ethiopia public health facilities: a retrospective cohort study. AIDS Res Ther. 2020;17(1):49.
Wondimu W, Dube L, Kabeta T. Factors affecting survival rates among adult TB/HIV co-infected patients in Mizan Tepi University teaching hospital, South West Ethiopia. HIV AIDS (Auckl). 2020;12:157–64.
Barata TY, et al. Incidence of mortality and its predictors among adult human immune virus infected patients on antiretroviral therapy in Wolaita Sodo University comprehensive specialized Hospital, Southern Ethiopia: a retrospective follow-up study. HIV AIDS (Auckl). 2023;15:361–75.
Teshale AB, Tsegaye AT, Wolde HF. Incidence of mortality and its predictors among HIV positive adults on antiretroviral therapy in University of Gondar comprehensive specialized Hospital, Northwest Ethiopia. HIV AIDS (Auckl). 2021;13:31–9.
Tesfayohannes S, et al. Mortality and its predictors among adult human immune-deficiency virus-infected patients attending their antiretroviral treatment at health centers, Addis Ababa, Ethiopia: multicenter retrospective cohort study. AIDS Res Treat. 2022;2022:6128718.
Ahunie MA, Ebrahim EA. Mortality predictors of HIV-infected patients on antiretroviral therapy in Debre Tabor General Hospital and Woreta Health Center, South Gondar Zone, Northwest Ethiopia. Asian Pacific J Trop Dis. 2017;7(2):99–105.
Mulissa Z, Jerene D, Lindtjorn B. Patients present earlier and survival has improved, but pre-ART attrition is high in a six-year HIV cohort data from Ethiopia. PLoS one. 2010;5(10):e13268.
Setegn T, et al. Predictors of mortality among adult antiretroviral therapy users in Southeastern Ethiopia: retrospective cohort study. AIDS Res Treat. 2015;2015:148769.
Birhanu A, Dingeta T, Tolera M. Predictors of mortality among adult HIV-infected patients taking Antiretroviral Therapy (ART) in Harari Hospitals, Ethiopia. HIV AIDS (Auckl). 2021;13:727–36.
Eticha EM, Gemeda AB. Predictors of mortality among adult patients enrolled on Antiretroviral Therapy in Hiwotfana specialized University Hospital, Eastern Ethiopia: retrospective cohort study. J HIV Clin Sci Res. 2018;5(1):007–11.
Biadgilign S, Reda AA, Digaffe T. Predictors of mortality among HIV infected patients taking antiretroviral treatment in Ethiopia: a retrospective cohort study. AIDS Res Ther. 2012;9(12):15.
Tadesse K, Haile F, Hiruy N. Predictors of mortality among patients enrolled on antiretroviral therapy in Aksum hospital, northern Ethiopia: a retrospective cohort study. PLoS One. 2014;9(1):e87392.
Workie KL, Birhan TY, Angaw DA. Predictors of mortality rate among adult HIV-positive patients on antiretroviral therapy in Metema Hospital, Northwest Ethiopia: a retrospective follow-up study. AIDS Res Ther. 2021;18(1):27.
Fekade D, et al. Predictors of survival among adult Ethiopian patients in the national ART program at seven University teaching Hospitals: a prospective cohort study. Ethiop J Health Sci. 2017;27(Suppl 1):63–71.
Mengesha S, Belayihun B, Kumie A. Predictors of survival in HIV-infected patient after initiation of HAART in Zewditu Memorial Hospital, Addis Ababa, Ethiopia. Int Sch Res Notices. 2014;2014:250913.
Birhanu H, Alle A, Birhanu MY. Rate and predictors of mortality among adults on antiretroviral therapy at Debre Markos Referral Hospital, North West Ethiopia. HIV AIDS (Auckl). 2021;13:251–9.
Seyoum D, et al. Risk factors for mortality among adult HIV/AIDS patients following antiretroviral therapy in Southwestern Ethiopia: an assessment through survival models. Int J Environ Res Public Health. 2017;14(3):296.
Salih AM, Yazie TS, Gulente TM. Survival analysis and predictors of mortality among adult HIV/AIDS patients initiated antiretroviral therapy from 2010 to 2015 in Dubti General Hospital, Afar, Ethiopia: a retrospective cohort study. Heliyon. 2023;9(1):e12840.
Yohannes T, Moges S, Laelago T. Survival analysis of adult human immune virus infected patients under antiretroviral treatment at Wachamo University. Int J Intern Med Geriatr. 2019;1(1):21–32.
Damtew B, Mengistie B, Alemayehu T. Survival and determinants of mortality in adult HIV/Aids patients initiating antiretroviral therapy in Somali Region, Eastern Ethiopia. Pan Afr Med J. 2015;22:138.
Nigussie F, et al. Survival and predictors of mortality among adult HIV/AIDS patients initiating highly active antiretroviral therapy in Debre-Berhan Referral Hospital, Amhara, Ethiopia: a retrospective study. HIV AIDS (Auckl). 2020;12:757–68.
Getaneh Y, et al. Survival and predictors of mortality among adults initiating highly active antiretroviral therapy in Ethiopia: a retrospective cohort study (2007–2019). Biomed Res Int. 2022;2022:5884845.
Digaffe T, Seyoum B, Oljirra L. Survival, and predictors of mortality among adults on antiretroviral therapy in selected public Hospitals in Harar, Eastern Ethiopia. J Trop Dis. 2014;02(05).
Abuto W, et al. Survival and predictors of mortality among HIV positive adult patients on highly active antiretroviral therapy in public Hospitals of Kambata Tambaro Zone, Southern Ethiopia: a retrospective cohort study. HIV AIDS (Auckl). 2021;13:271–81.
Tachbele E, Ameni G. Survival and predictors of mortality among human immunodeficiency virus patients on anti-retroviral treatment at Jinka Hospital, South Omo, Ethiopia: a six years retrospective cohort study. Epidemiol Health. 2016;38:e2016049.
Sapa WB, Negassi NT, and A.H. Chofore, survival pattern and its determinants among adult HIV-infected patients after initiation of HAART in Dilla Hospital Ethiopia. J Clin Exp Immunol. 2016;1(1):2–6.
Demissie MW. Statistical modeling for the survival of HIV/AIDS patients treated with Highly Active Anti-Retroviral Therapy (HAART): a case study at Dilchora Hospital, Dire Dawa, Ethiopia. J Biom Biostat. 2018;9(5):1–10.
Lelisho ME, et al. Survival rate and predictors of mortality among TB/HIV co-infected adult patients: retrospective cohort study. Sci Rep. 2022;12(1):18360.
Refera H, Wencheko E. Survival of HIV-TB co-infected adult patients under ART in Ambo Referral Hospital, Ethiopia. Ethiop J Health Dev. 2013;27(2):88–93.
Deres G, et al. Survival time and associated factors among adults living with hiv after initiation of HAART in South Gondar, Northwest Ethiopia: a retrospective cohort. J Multidiscip Healthc. 2021;14:1463–74.
Siraj M, Gedamu S, Tegegne B. Predictors of survival time among HIV-infected adults after initiating anti-retroviral therapy in Kombolcha Town: a 5-year retrospective cohort study. HIV AIDS (Auckl). 2022;14:181–94.
Kebebew K, Wencheko E. Survival analysis of HIV-infected patients under antiretroviral treatment at The Armed Forces General Teaching Hospital, Addis Ababa, Ethiopia. Ethiop J Health Dev. 2012;26(3):186–92.
Joseph N, et al. Prognostic factors of mortality among adult patients on antiretroviral therapy in India: a hospital-based retrospective cohort study. BioMed Res Int. 2019;2019:1419604.
Collaboration, A.T.i.L.I.C. and A.C. Collaboration, Mortality of HIV-1-infected patients in the first year of antiretroviral therapy: comparison between low-income and high-income countries. Lancet. 2006;367(9513):817–24.
MacPherson P, et al. Mortality and loss to follow-up among HAART initiators in rural South Africa. Trans R Soc Trop Med Hyg. 2009;103(6):588–93.
Bajpai R, et al. Effects of antiretroviral therapy on the survival of human immunodeficiency virus-positive adult patients in Andhra Pradesh, India: a retrospective cohort study, 2007–2013. J Prev Med Public Health. 2016;49(6):394.
Abaasa AM, et al. Good adherence to HAART and improved survival in a community HIV/AIDS treatment and care program: the experience of The AIDS Support Organization (TASO), Kampala Uganda. BMC Health Serv Res. 2008;8:1–10.
Mugenyi L, et al. Effect of universal test and treatment on retention and mortality among people living with HIV-infection in Uganda: an interrupted time series analysis. PLoS One. 2022;17(5):e0268226.
Bekolo CE, et al. Universal test and treat in Cameroon: a comparative retrospective analysis of mortality and loss to follow-up before and after a strategic change in approach to HIV care. Pan Afr Med J. 2023;45:191.
Mugusi FM, et al. Factors associated with mortality in HIV-infected and uninfected patients with pulmonary tuberculosis. BMC Public Health. 2009;9(1):1–8.
Domingos MP, Caiaffa WT, Colosimo EA. Mortality, TB/HIV co-infection, and treatment dropout: predictors of tuberculosis prognosis in Recife, Pernambuco State, Brazil. Cadernos Saude Publica. 2008;24:887–96.
Stervbo U, et al. Effects of aging on human leukocytes (part I): immunophenotyping of innate immune cells. Age (Dordr). 2015;37(5):92.
Sieleunou I, et al. Determinants of survival in AIDS patients on antiretroviral therapy in a rural centre in the Far-North Province, Cameroon. Trop Med Int Health. 2009;14(1):36–43.
Gupta A, et al. Early mortality in adults initiating antiretroviral therapy (ART) in low-and middle-income countries (LMIC): a systematic review and meta-analysis. PLoS One. 2011;6(12):e28691.
Alibhai A, et al. Gender-related mortality for HIV-infected patients on highly active antiretroviral therapy (HAART) in rural Uganda. Int J Womens Health. 2010;2:45–52.
Woldegeorgis BZ, et al. Incidence and predictors of opportunistic infections in adolescents and adults after the initiation of antiretroviral therapy: a 10-year retrospective cohort study in Ethiopia. Front Public Health. 2022;10:1064859.
Nicastri E, et al. Sex issues in HIV-1-infected persons during highly active antiretroviral therapy: a systematic review. J Antimicrob Chemother. 2007;60(4):724–32.
Araujo Chaveron L. et al. Injecting drug use increases the risk of death in HIV patients on antiretroviral therapy in Vietnam. AIDS Care. 2023:1–10. https://doi.org/10.1080/09540121.2023.2224549.
Petoumenos K, Law MG. Smoking, alcohol and illicit drug use effects on survival in HIV-positive persons. Curr Opin HIV AIDS. 2016;11(5):514–20.
Alema HB, et al. HIV positive status disclosure and associated factors among HIV positive adults in Axum health facilities, Tigray, Northern Ethiopia. Sci J Public Health. 2015;3(1):61.
Mi T, et al. HIV disclosure to family members and medication adherence: role of social support and self-efficacy. AIDS Behav. 2020;24(1):45–54.
Dessie G, et al. The effect of disclosure on adherence to antiretroviral therapy among adults living with HIV in Ethiopia: a systematic review and meta-analysis. BMC Infect Dis. 2019;19(1):528.
Yehualashet F, et al. Human immunodeficiency virus positive status disclosure to a sexual partner and its determinant factors in Ethiopia: a systematic review and meta-analysis. BMC Infect Dis. 2020;20(1):1–14.
da Silva Escada RO, et al. Mortality in patients with HIV-1 and tuberculosis co-infection in Rio de Janeiro, Brazil-associated factors and causes of death. BMC Infect Dis. 2017;17(1):1–10.
Ismail I, Bulgiba A. Predictors of death during tuberculosis treatment in TB/HIV co-infected patients in Malaysia. PLoS One. 2013;8(8):e73250.
Johannessen A, et al. Predictors of mortality in HIV-infected patients starting antiretroviral therapy in a rural hospital in Tanzania. BMC Infect Dis. 2008;8:1–10.
Johansson KA, Robberstad B, Norheim OF. Further benefits by early start of HIV treatment in low income countries: survival estimates of early versus deferred antiretroviral therapy. AIDS Res Ther. 2010;7:1–9.
Mocroft A, et al. Anaemia is an independent predictive marker for clinical prognosis in HIV-infected patients from across Europe. AIDS. 1999;13(8):943–50.
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