Signs of STD

Mpox (formerly known as monkeypox) and chickenpox are two contagious viral diseases. They both have "pox" in their names because they cause pockmark skin lesions. But mpox is caused by a virus similar to smallpox, while a type of herpesvirus causes chickenpox. While they share similar symptoms (like fever, fatigue, headaches, and a blistering rash), mpox and chickenpox differ by how the viruses are spread, the locations of the rashes, the populations they most commonly affect, and how each is treated. This article describes the differences between mpox and chickenpox in symptoms, causes, diagnosis, and treatment. If you have a rash, be sure to see a healthcare provider for a diagnosis so that you can receive the appropriate treatment. rbkomar / Getty Images Symptoms No less than three dozen viral diseases have "pox" in their names, the most familiar of which are chickenpox, smallpox, and mpox. All of these diseases s...

The FDA announced that the Oncologic Drugs Advisory Committee (ODAC) will meet March 9 to review the accelerated approval of polatuzumab vedotin (Polivy) plus rituximab (Rituxan) and chemotherapy for untreated diffuse large B-cell lymphoma. Janssen and Legend Biotech announced early termination of a phase III trial after an interim analysis showed that ciltacabtagene autoleucel (cilta-cel, Carvykti) met the primary endpoint of improved progression-free survival in lenalidomide (Revlimid)-refractory multiple myeloma versus two active control regimens. Where does your state fall in the American Lung Association's annual list of tobacco-control efforts? In studies involving artificial human skin, scientists prevented development of invasive skin cancer in a laboratory model. ( University of Copenhagen , Science Signaling ) Combining immunotherapy and targeted therapy led to durable responses in a difficult-to-treat form of colon cancer . ( Mass General Cancer Center , Nature M...

Former Wales international Gareth Thomas (David Davies/PA). (PA Archive) Gareth Thomas has settled a legal case with an ex-partner who accused the former Wales captain of "deceptively" transmitting HIV to him. Ian Baum sued Mr Thomas in the High Court for allegedly hiding his HIV status and "failing to take reasonable care" not to pass the virus on. Mr Thomas will pay £75,000 plus costs but said he has not admitted liability by settling, adding that he maintains his innocence "in all the meritless allegations". Mr Baum, a former police constable who was in a relationship with the rugby star between 2013 and 2016, claimed he was HIV negative when they got together, court papers said. Ian stood up for himself against the odds. Ian is looking forward to putting this unpleasant chapter of his life behind him McCue Jury and Partners The documents said Mr Baum noticed the sportsman was taking pills from bottles which had the labels ripped off them but was told t...

Although PID and endometriosis have similar symptoms, they are two different conditions. What's the short answer? Pelvic inflammatory disease (PID) is a bacterial infection of the reproductive organs. Endometriosis is specifically caused by the tissue that lines the uterus — called endometrial tissue — forming outside of the uterus. This misplaced tissue can cause inflammation and pain. PID and endometriosis share similar symptoms, but they're two different conditions. What are the symptoms of each condition? Pelvic inflammatory disease Not everybody with PID experiences symptoms. However, if you do have symptoms, you might experience the following: abdominal pain (most commonly in the lower abdomen) fatigue fever pain during penetrative sex pain during urination increased or foul-smelling vaginal discharge irregular bleeding In some cases, you might experience more extreme symptoms, including: fainting fever greater than 101°F (38.3°C) sharp, severe pain in the abdomen vomitin...

More than 80 people have died from the coronavirus in China. The Chinese government is turning to a drug developed by AbbVie for HIV patients as a potential treatment for the outbreak that has reached the shores of the United States. AbbVie said it was donating more than one million dollars' worth of Aluvia, a combination of lopinavir and ritonavir as an ad-hoc treatment for pneumonia that is associated with the outbreak. The Chinese government suggested last week that taking two lopinavir/ritonavir pills and inhaling a dose of nebulized alpha-interferon twice a day could benefit these patients, Reuters reported. There are more than 2,000 known cases of the coronavirus in China. The illness has caused parts of China to grind to a halt as health officials seek to contain the spread of the virus. The decision to use AbbVie's medicine came after a noted respiratory expert at Peking University First Hospital in Beijing said he was given the HIV drugs to fight the virus ...

Abstract Metabolic changes in immune cells contribute to both physiological and pathophysiological outcomes of immune reactions. Here, by comparing protein expression, transcriptome, and salivary metabolome profiles of uninfected and HIV+ individuals, we found perturbations of polyamine metabolism in the oral mucosa of HIV+ patients. Mechanistic studies using an in vitro human tonsil organoid infection model revealed that HIV infection of T cells also resulted in increased polyamine synthesis, which was dependent on the activities of caspase-1, IL-1β, and ornithine decarboxylase-1. HIV-1 also led to a heightened expression of polyamine synthesis intermediates including ornithine decarboxylase-1 as well as an elevated dysfunctional regulatory T cell (T regDys )/T helper 17 (Th17) cell ratios. Blockade of caspase-1 and polyamine synthesis intermediates reversed the T regDys phenotype showing the direct role of polyamine pathway in altering T cell functions during HIV-1 infection. Lastly...

Understanding HIV latency at the molecular level is crucial for efforts to eliminate the viral scourge that causes AIDS. Latent infected cell reservoirs -- where the human immunodeficiency virus (HIV) hides and persists in the bodies of infected patients in a kind of silent standby mode -- are the reason why antiretroviral treatments never wipe out the virus. In a nutshell, these latent reservoirs of HIV act as the biggest obstacle to curing the disease. Now, in a rigorous new study led by uOttawa Faculty of Medicine virologist Dr. Marc-André Langlois, researchers are describing an against-the-grain discovery that is a potential game changer in the field. It has the potential to show the way forward for HIV cure research. Published today in Nature Communications , the findings demonstrate that a family of host proteins long thought of as purely antiviral are sometimes also helping latent HIV find safe harbor in patients' bodies. Using cutting-edge technology and methodical...

The study design and methodology for the parent clinical trial have been published previously [9]. In summary, PWH over 18 years of age on antiretroviral therapy were recruited into a randomized open—label phase III clinical trial. Participants were randomized in a 1:1:1 ratio to (1) continue standard of care of daily TS prophylaxis (160 mg trimethoprim/ 800 mg sulfamethoxazole), (2) discontinue TS prophylaxis and begin weekly CQ prophylaxis (300–310 mg chloroquine base), or (3) discontinue TS prophylaxis. Participants were followed up every 4–12 weeks, and whenever they were ill. Study participants were recruited from two sites in Malawi: Ndirande research clinic in Blantyre, an urban centre, and Tisungane ART clinic at Zomba Central Hospital, located in a more rural setting. Of note, the two sites have different malaria burdens: malaria parasite prevalence in children under 5 years old is 4% in Ndirande versus 28% in Zomba [10]. P...